2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-121899R
    1-Oxo Ibuprofen (Standard)
    1-Oxo Ibuprofen (Standard) is the analytical standard of 1-Oxo Ibuprofen. This product is intended for research and analytical applications. 1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
    1-Oxo Ibuprofen (Standard)
  • HY-W354479
    6-Thioinosine Phosphate
    6-Thioinosine Phosphate (Thioinosinic acid) is an intermediate metabolite of azathioprine (HY-B0256). Azathioprine is a purine analog immunosuppressive drug.
    6-Thioinosine Phosphate
  • HY-W013186S1
    Lansoprazole Sulfide-13C6
    Lansoprazole Sulfide-13C6 is a deuterated labeled Lansoprazole Sulfide.
    Lansoprazole Sulfide-<sup>13</sup>C<sub>6</sub>
  • HY-135577
    β-Apooxytetracycline
    β-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is a widespread antibiotic.
    β-Apooxytetracycline
  • HY-100085R
    21-Desacetyldeflazacort (Standard)
    21-Desacetyldeflazacort (Standard) is the analytical standard of 21-Desacetyldeflazacort. This product is intended for research and analytical applications. 21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration.
    21-Desacetyldeflazacort (Standard)
  • HY-W278566
    Saluamine
    Saluamine is a metabolite of Furosemide (HY-B0135).
    Saluamine
  • HY-12765R
    Losartan Carboxylic Acid (Standard)
    Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[4].
    Losartan Carboxylic Acid (Standard)
  • HY-G0011
    Netupitant metabolite Netupitant N-oxide
    Netupitant N-oxide is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.
    Netupitant metabolite Netupitant N-oxide
  • HY-131272R
    Febuxostat dicarboxylic acid impurity (Standard)
    Febuxostat dicarboxylic acid impurity (Standard) is the analytical standard of Febuxostat dicarboxylic acid impurity. This product is intended for research and analytical applications. Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat dicarboxylic acid impurity (Standard)
  • HY-A0019R
    Paliperidone (Standard)
    Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia.
    Paliperidone (Standard)
  • HY-G0010S
    N-desmethyl Netupitant-d6
    N-desmethyl Netupitant-d6 is the deuterium labeled N-desmethyl Netupitant, which is a metabolite of Netupitant.
    N-desmethyl Netupitant-d<sub>6</sub>
  • HY-135731AR
    4-Methylamino antipyrine hydrochloride (Standard)
    4-Methylamino antipyrine (hydrochloride) (Standard) is the analytical standard of 4-Methylamino antipyrine (hydrochloride). This product is intended for research and analytical applications. 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties.
    4-Methylamino antipyrine hydrochloride (Standard)
  • HY-10002R
    Calcitriol (Standard)
    Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
    Calcitriol (Standard)
  • HY-135397R
    (R)-​Linezolid (Standard)
    (R)-​Linezolid (Standard) is the analytical standard of (R)-​Linezolid. This product is intended for research and analytical applications. (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis.
    (R)-​Linezolid (Standard)
  • HY-137575
    Terbutalone
    Terbutalone is a derivative of Terbutaline (HY-B0802A). Terbutaline is an orally active β2-adrenergic receptor agonist and an active metabolite of Bambuterol (HY-17501). Terbutaline can be used in asthma symptom research.
    Terbutalone
  • HY-Y1771R
    2-Carboxybenzaldehyde (Standard)
    2-Carboxybenzaldehyde (Standard) is the analytical standard of 2-Carboxybenzaldehyde. This product is intended for research and analytical applications. 2-Carboxybenzaldehyde is the major metabolite found in phenanthrene metabolism. Phenanthrene can be degrade by Pseudomonas sp. Lphe-2 strain.
    2-Carboxybenzaldehyde (Standard)
  • HY-G0005
    Duloxetine metabolite Para-Naphthol Duloxetine
    Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI).
    Duloxetine metabolite Para-Naphthol Duloxetine
  • HY-W003371R
    CGP 44 645 (Standard)
    CGP 44 645 (Standard) is the analytical standard of CGP 44 645. This product is intended for research and analytical applications. CGP 44 645 is the methanol metabolite of Letrozole (HY-14248) and is a molecular indicator for evaluating its metabolic kinetics in microsomes in vitro. Levels of CGP 44 645 in rat liver microsomes may be sex-specific.
    CGP 44 645 (Standard)
  • HY-137193
    5,6-Dihydroabiraterone
    5,6-Dihydroabiraterone is the metabolism of Abiraterone (HY-70013). Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, and shows antitumor activity in CRPC (castration-resistant prostate cancer).
    5,6-Dihydroabiraterone
  • HY-W019773R
    Albendazole sulfone (Standard)
    Albendazole sulfone (Standard) is the analytical standard of Albendazole sulfone. This product is intended for research and analytical applications. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
    Albendazole sulfone (Standard)
Cat. No. Product Name / Synonyms Application Reactivity